Structure-Guided Discovery Without Structures: Computer-aided design of GPCR ligands
G-protein coupled receptors (GPCRs) account for the majority of best-selling drugs and about 40% of all prescription pharmaceuticals on the market. Despite the importance of this target class, experimental structural information is scarce for these targets and hence the well-established methods of computer-aided design are less applicable to GPCRs. In this talk, case-studies of successful computer-guided design will be presented. It is argued that, despite the lack of experimental structures, computer-aided design can strongly contribute also to the success of GPCR drug discovery.
Presenter: Dr Miklos Feher, Group Leader, Computational Chemistry, The Campbell Family Institute for Breast Cancer Research (UHN)
11:30AM - 1:00PM
MaRS Centre, CR2
101 College St.
Toronto, ON
Bring your own lunch
Register now
Dr Feher has a M.Sc in chemistry from the Technical University of Budapest and a PhD in Physical Chemistry from Southampton University.
Presenter: Dr Miklos Feher, Group Leader, Computational Chemistry, The Campbell Family Institute for Breast Cancer Research (UHN)
DATE | TIME | LOCATION
March 27, 200811:30AM - 1:00PM
MaRS Centre, CR2
101 College St.
Toronto, ON
Bring your own lunch
REGISTRATION
Registration is free but required.Register now
ABOUT THE SPEAKER
Dr Feher , currently the computational chemistry group Leader at the Campbell Family Institute for Breast Cancer Research (UHN), has over 20 years of experience in the field. Dr Feher has lead computational chemistry efforts at Neurocrine Biosciences, SignalGene Inc and Sanofi Aventis. Prior to joining industry, Dr Feher was a faculty member at University of Basel. He has authored/co-authored more than 90 peer-reviewed publications and two textbooks.Dr Feher has a M.Sc in chemistry from the Technical University of Budapest and a PhD in Physical Chemistry from Southampton University.
UPCOMING EVENTS
PAST EVENTS
- March 27, 2008
MaRS Drug Development Discussion Group - Structure-Guided Discovery Without Structures: Computer-aided design of GPCR ligands - February 27, 2008
MaRS Drug Development Discussion Group - Formulation: Giving new life to naturally occurring un-patentable compounds - January 25, 2008
Drug Development Discussion Group - Novel therapeutic targets for preventing bone loss in osteolytic disease - December 18, 2007
MaRS Drug Development Discussion Group - Outsourcing Preclinical Development - October 23, 2006
MaRS Drug Development Discussion Group - Chance and Necessity in Drug Discovery: The case history of calcimimetic drugs - August 31, 2006
Drug Development Discussion Group - Structure-based Lead Generation and Optimization - June 29, 2006
Drug Development Discussion Group - Exploratory IND - April 27, 2006
Drug Discussion Group - BioMarkers in Clinical Trials
