Novel therapeutic targets for preventing bone loss in osteolytic disease
ABOUT THE SPEAKER
Dr. Morris Frank Manolson is an associate professor at the Faculty of Dentistry, University of Toronto. The goal of his research is trying to prevent the pathological bone loss associated with osteoporosis and inflammatory arthritis. We now know that the cells responsible for this bone loss (osteoclasts) resorb bone by pumping acid directly onto the bone surface; the secreted acid literally dissolving the bone surface away. In inflammatory arthritis, this normal process of bone resorption becomes pathologically accelerated and results in an overall loss of bone around the arthritic joints. Dr. Manolson's work has been to advance our understanding of exactly how the osteoclast acid pumps (V-ATPases) pump the acid onto the bone. With knowledge of the osteoclast acid pump, Dr. Manolson's is now focused on trying to develop therapeutic reagents that will specifically stop the acid pumps in order to prevent the accelerated bone loss associated with inflammatory types of arthritis, such as rheumatoid arthritis, psoriatic arthritis, and reactive arthritis. His talk will cover his strategy for selecting a drug target, its validation, and approach to screening agents.DATE | TIME | LOCATION
January 25, 200811:30AM - 1:00PM
MaRS Centre
101 College St.
Toronto, ON
CR-3
Registration is free.
Bring your lunch.
Register now
UPCOMING EVENTS
PAST EVENTS
- March 27, 2008
MaRS Drug Development Discussion Group - Structure-Guided Discovery Without Structures: Computer-aided design of GPCR ligands - February 27, 2008
MaRS Drug Development Discussion Group - Formulation: Giving new life to naturally occurring un-patentable compounds - January 25, 2008
Drug Development Discussion Group - Novel therapeutic targets for preventing bone loss in osteolytic disease - December 18, 2007
MaRS Drug Development Discussion Group - Outsourcing Preclinical Development - October 23, 2006
MaRS Drug Development Discussion Group - Chance and Necessity in Drug Discovery: The case history of calcimimetic drugs - August 31, 2006
Drug Development Discussion Group - Structure-based Lead Generation and Optimization - June 29, 2006
Drug Development Discussion Group - Exploratory IND - April 27, 2006
Drug Discussion Group - BioMarkers in Clinical Trials
