
En route to becoming a billion-dollar enterprise, a company must establish the milestones needed to build value and attract more investors. “Then it must meet its next milestone in order to reach the subsequent level of investment,” Cruz said.
Among the daunting challenges, is the ten to fourteen years required to go from a lead molecule, through preclinical and clinical stages, and finally to drug approval. Along the way, cash-seeking companies need to make decisions like when to go public or when to merge with a public company — bearing in mind all the additional pressure, accountability and disclosure these moves entail.
Cruz thinks entrepreneurs also have to be ready to kill a product too beset with hurdles and to acquire promising properties. “If you see a molecule that’s better than yours, grab it,” he said. And to obtain cash for continued research, entrepreneurs must be ready to sell their companies strategically. “In biotech, you have to go where the market is. Flexibility is all-important.”
Navigating the road from a lead molecule to successful company requires decisiveness, partnering and financing — all supported by a great deal of scientific, legal, corporate and business expertise. In light of these factors, Cruz advises the audience to “stay passionate — biotech is not just a business.”
To learn more about Transition Therapeutics, visit: www.transitiontherapeutics.com