Heritage building historical timeline

 

Insulin

30 October, 1920

Frederick Banting conceives an idea for extracting an anti-diabetic pancreatic secretion.
8 November, 1920  

Banting meets with J.J.R. Macleod, who assigns him a lab and Charles Best as a research assistant.
May 1921

Banting and Best begin laboratory work.
December, 1921

J.B. Collip, a specialist in tissue extracts, joins the team.
11 January, 1922

First human test on Leonard Thomson. Results are promising, but toxic side-effects prevent further testing.
23 January, 1922

Thomson tested again with a refined extract. All symptoms of his diabetes ‘miraculously’ disappear.
22 March, 1922

Team publishes its findings, prompting a flurry of media and public attention.
March-May, 1922
Collip temporarily loses ability to produce insulin. Insulin Committee (IC) is created to expand the resource base to develop Insulin for mass-production.
30 May, 1922

IC licenses U.S.A. production rights to Eli Lilly & Co.
November, 1922

IC grants development and production rights to Britain’s “Medical Research Council” and Denmark’s “Nordisk Insulinlaboratorium”.
Late 1923

Mass-production of Insulin begins.

 

 

Heparin and its Surgical Applications

1917
Crude, highly toxic form of Heparin discovered at Johns Hopkins University.
1929
Charles Best assigns project of purifying heparin to D.A. Scott and A.F. Charles of Connaught Laboratories.
1933-34
Efficient Heparin production method established.
6 April, 1935

Gordon Murray administers the first clinical test of Heparin.
1946
Murray develops surgical cure for Blue Baby Syndrome
6 December, 1946 Murray tests North America’s first artificial kidney on a human subject
2 May, 1952

Murray performs first human kidney transplant
November 1955

Raymond Heimbecker performs the first successful human heart valve transplant.
1947
William Bigelow begins testing use of hypothermia in open-heart surgery.
1950
Bigelow develops and tests the first artificial pacemaker
 
 
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