Dr. Andras Nagy, PhD
Transposition reprogrammed induced pluripotent stem cells are powerful tools
Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Professor, Department of Molecular Genetics, University of Toronto
Investigator, McEwen Centre for Regenerative Medicine
In 2005, Dr. Nagy’s lab created the first two Canadian hES cell lines which have opened a new area of research leading toward ES cell based therapies for incurable diseases. Using a novel method, they generated induced pluripotent stem cells (iPS) from both mouse and human somatic cells using the piggyBac transposon system. The transposon system also allows for the removal of the reprogramming factors from the iPS cell which is a leap forward for the safe use of these stem cells in future stem cell-based therapies. These are the first non-viral transduction iPS cell line, which keeps them at a leadership position in this highly competitive and promising field of research.
