Complexation Research Assistant (Fall 2018 Position)
Position Role: Research
Position Level: Internship
Position Type: Contract
Position Location: Guelph, ON
Application Deadline: 2018-08-02
This position is offered in part by the MaRS Student Work-Integrated Learning (WIL) Program, which connects post-secondary students with work placements in technology and business.
Position Start Date: September 3, 2018
Position End Date: April 26, 2019
Glysantis (Mirexus Biotechnologies Inc.) is a biotech company active in pre-clinical research & development. Our core technology – NanoDendrixTM – is based on highly branched, plant-derived phytoglycogen nanoparticles. NanoDendrixTM particles are monodisperse (uniform in size), water soluble, all-natural and biodegradable, non-toxic, and have tunable surface chemistry allowing for desirable modifications. The company’s mission is to transfer our innovative nanoparticle platform technology to a wide range of biomedical applications.
Our company offers a multi-cultural and diverse team of supportive and close-knit employees (<30 people), with areas of expertise in multiple fields including microbiology, molecular biology, physics, food science, nanoscience, chemistry, cosmetics, business development, etc.). Since most employees at Glysantis/Mirexus have a strong background in science, the company hosts events including “business-like thinking day”, which allows all employees and students to discuss topics outside their field of focus, such as aspects of marketing, business development, sales, and how our company is doing in each of these areas. Our growth and success stories (e.g. with international distributors) are also shared at monthly town hall meetings. As Mirexus is expanding, we have built a factory and are moving to our new facility this year (April-May 2018).
Glysantis, Chemistry Department:
The person hired to this position will join a team of multi-disciplinary researchers who will provide one-on-one feedback and suggestions for project advancement at weekly group meetings. Current work at Glysantis can be classified into three main areas: immunomodulation, drug delivery, and anti-infectives. In addition to in-house laboratory facilities in Ontario, Glysantis has partnerships with commercial research organizations and academic collaborations with researchers from Canadian as well as international universities.
In this project, various nanoparticle/drug formulations will be prepared through physical adhesion techniques which avoid the use of extraneous chemical reagents. The goal is to use native glycogen particles, which are viewed as a natural resource and nutrient to the cell, to enable enhanced cellular uptake of the complexed bioactive compounds. To quantify the loading of bioactive material, separation techniques such as dialysis, centrifugal filtration and high-performance liquid chromatography will be used, and products will be analyzed by UV-Vis and nuclear magnetic resonance spectroscopy, as well as differential scanning calorimetry. The novel materials created in this work will be screened for biological efficacy such as anti-microbial activity in vitro, functional assays on cell culture, transport across biological membranes, and immunologic studies.
The student will perform physical processing techniques known to cause adhesion or complexation of bioactive drugs to the glycogen carrier, including spray-drying, freeze-drying, sonication, homogenization and treatment with ionic species. HPLC and various spectroscopic techniques will also be used to analyze the stability, solubility, and degree of substitution to the glycogen carrier. Training of techniques will be provided as necessary.
- Use of Excel, Word, and PowerPoint.
- Previous project work in a (synthetic) chemistry lab.
Area of study:
Chemistry, synthetic chemistry, nanotechnology, biochemistry, biological and pharmaceutical chemistry
Familiarity with standard lab techniques (e.g. pipetting, centrifugation) and lab safety (i.e. WHMIS).
The applicant will be detail-oriented and conscientious, with strong record keeping skills, the ability to think critically and work with minimal supervision, and to effectively communicate observations and findings.
How to Apply: