Conjugation Chemistry Research Assistant (Fall 2018 Position)
Position Role: Research
Position Level: Internship
Position Type: Contract
Position Location: Toronto
Application Deadline: 2018-08-02
This position is offered in part by the MaRS Student Work-Integrated Learning (WIL) Program, which connects post-secondary students with work placements in technology and business.
Position Start Date: September 3, 2018
Position End Date: April 26, 2019
Glysantis (Mirexus Biotechnologies Inc.) is a biotech company active in pre-clinical research & development. Our core technology – NanoDendrixTM – is based on highly branched, plant-derived phytoglycogen nanoparticles. NanoDendrixTM particles are monodisperse (uniform in size), water soluble, all-natural and biodegradable, non-toxic, and have tunable surface chemistry allowing for desirable modifications. The company’s mission is to transfer our innovative nanoparticle platform technology to a wide range of biomedical applications.
Our company offers a diverse team of supportive and close-knit employees (<30 people), with areas of expertise in fields including microbiology, molecular biology, physics, food science, nanoscience, chemistry, cosmetics, business development, etc.). Since most employees at Glysantis/Mirexus have a strong background in science, the company hosts events including “business- like thinking day”, which allows all employees and students to discuss topics outside their field of focus, such as aspects of marketing, business development, sales, and how our company is doing in each of these areas. Growth and success stories (e.g. forming collaborations with international distributors) are also shared at monthly town hall meetings. Mirexus has expanded to build a factory, and we are moving into our new facility this year (April-May 2018).
Glysantis, Chemistry Department:
The person hired to this position will join a team of multi-disciplinary researchers and will conduct various chemical derivatizations to prepare novel nanoparticle-drug conjugates, which will be tested by our collaborators for enhancement in biological activity. Current work at Glysantis can be classified into three main areas: immunomodulation, drug delivery, and anti-infectives. In addition to in-house laboratory facilities in Ontario, Glysantis has partnerships with commercial research organizations and academic collaborations with researchers from Canadian as well as international universities.
In this project, nanoparticle-drug conjugates will be synthesized to improve the drug’s efficacy. The conjugate products will be characterized using spectroscopic methods such as UV-Vis, nuclear magnetic resonance (NMR), dynamic light scattering (DLS), as well as chromatographic methods including high-performance liquid chromatography (HPLC) to determine the stability, solubility, and degree of substitution of the products. The new materials developed in this project will be screened for anti- microbial activity in vitro, as well as for cell toxicity, to prove enhanced delivery, cellular uptake, and biological activity of the drugs.
The student will prepare various phytoglycogen-drug conjugates through applying coupling chemistry techniques to NanoDendrixTM particles, learn and implement various processing methods such as lyophilization, spray drying, dialysis, micro/ultrafiltration and centrifugal filtration, and characterize the products using analytical techniques including UV-Vis, NMR, DLS, SEC, HPLC, DSC and TGA. Training in requisite techniques will be provided as necessary.
- Use of Excel, Word, PowerPoint
- Previous project work in a (synthetic) chemistry lab.
Area of Study:
Chemistry, synthetic chemistry, nanotechnology, biochemistry, biological and pharmaceutical chemistry
Familiarity with standard lab techniques (e.g. pipetting, centrifugation) and lab safety (i.e. WHMIS) is required.
The applicant will be detail-oriented and conscientious, with strong record keeping skills, the ability to think critically and work with minimal supervision, and to effectively communicate observations and findings.
How to Apply: