Methodological Centres

EXCITE comprises five methodological centres (MCs) across Ontario.

MCs are academic units that have demonstrated experience and excellence in clinical trials methodology, health technology assessment and in conducting complex, multi-centre trials with proven capacity for data collection, synthesis and reporting.

They are responsible for overseeing the design and execution of EXCITE studies, sometimes in collaboration with one or more other institutions that have the appropriate capabilities/experience to complete evaluations successfully.

Meet the MCs:

The Applied Health Research Centre (AHRC) is a full-service, non-profit academic research organization (ARO) fully integrated with the Li Ka Shing Knowledge Institute (LKSKI) of St. Michael’s Hospital. Established in 2009, the AHRC is the only University of Toronto (U of T) affiliated non-profit ARO in Toronto. As a full-service clinical research coordinating centre, AHRC provides its clients with the academic and scientific leadership of a world-class academic medical centre and the operational excellence of a contract research organization (CRO).

The Programs for Assessment of Technology in Health (PATH) Research Institute consists of multiple research programs in economic evaluation and health technology assessment (HTA). PATH’s educational and research activities are separated into five primary programs: the Field Evaluation and Economic Assessment Program (FEEAP); the Health Technology Assessment Program (HTAP); the Trial and Economic Modeling Methodology Program (TEMMP); the St. Joseph’s Healthcare Hamilton (SJHH) Health Technology Assessment Appraisal & Review Program (SHARP); and the Health Technology Assessment Educational Learning Program (HELP). The PATH Research Institute is affiliated with the Centre for Evaluation of Medicines (CEM) at SJHH and the Department of Clinical Epidemiology and Biostatistics at McMaster University.

The Toronto Health Economics and Technology Assessment (THETA) Collaborative is a leading source of expertise in health technology assessment (HTA). Working closely with government, health service providers and health professionals, THETA conducts high quality HTA research that raises important questions and finds actionable answers: Better information. Better decisions. Better care. Established In 2007, THETA has quickly grown to become a strong Canadian base for HTA research—with 20 staff members, over 40 investigators, more than 30 HTA graduate students and a broad base of collaborators in industry, R&D and government. THETA has three divisions: the Health Modeling and Health Economics Division (produces high quality economic evidence to advise health policy decision makers in Ontario, and contributes to the development of health modeling and economics methodologies); the Clinical Research Division (design, implementation and evaluation of clinical trials and complex health system interventions using a mixed-methods approach); and the Health Policy and Ethics Division (advance efforts to incorporate ethics and social values into HTA research, and advance research into the role of HTA across the technology life cycle). THETA Collaborative is affiliated with the University Health Network, Leslie Dan Faculty of Pharmacy at the University of Toronto, and Institute of Health Policy, Management and Evaluation, at the University of Toronto.

Specialized methodological centres:

Optionally, EXCITE also provides an expanded range of offerings through specialized methodological centres that share their expertise in different areas, each of which is designed to enhance the scope of an evaluation.

Meet the specialized methodological centres